Weight · Rx required

The Kickstart Stack

The proven first step.

Tier 1 · FDA-approved / strong evidenceMost popular

The story

The proven first step. Semaglutide is the weekly GLP-1 injection behind today's biggest weight-loss results, paired with B12 to support energy while your appetite comes down. Everything you need to begin, in one kit.

Why this combination

Semaglutide does the heavy lifting on appetite. B12 supports energy and nutrient intake as you eat less — genuinely useful if you're running low. The syringes and swabs make weekly dosing easy and clean.

What to expect

In large trials, semaglutide produced ~15% average body-weight loss over ~18 months, with most people losing at least 5%, and it lowered major cardiovascular events in a large trial. Results build gradually as the dose steps up; works best with protein-forward eating and movement.

Risks & considerations

Gastrointestinal side effects (nausea, sometimes constipation/diarrhea) are common, worst during dose increases. Rare but serious: pancreatitis, gallbladder issues; boxed warning about rodent thyroid tumors (avoided with certain thyroid-cancer history). Some muscle is lost with fat — protein and resistance exercise matter. Weight tends to return if you stop.

Sources

  1. STEP 1, NEJM 2021
  2. STEP 5, Nature Medicine 2022
  3. SELECT, NEJM 2023

What's in the stack

  • Semaglutide + B12 injection
  • Insulin syringes
  • Alcohol swabs