← Weight · Rx required
The Heavy Hitter Stack
Dual-action weight support.
Tier 1 · FDA-approved / strong evidence
The story
Dual-action weight support. Tirzepatide works on two appetite hormones at once and has produced some of the largest weight-loss numbers ever recorded for a medication. Same supportive B12 and supplies as the Kickstart.
Why this combination
Tirzepatide hits both GLP-1 and GIP pathways, which in trials added up to more appetite control than GLP-1 alone. B12 steadies energy while intake drops.
What to expect
In SURMOUNT-1, average weight loss reached ~15–22.5% by dose over 72 weeks, with ~9 in 10 losing at least 5% at the top dose. Longer-term data showed sustained loss and reduced progression from prediabetes to diabetes. Dose climbs gradually.
Risks & considerations
Same gastrointestinal profile and rodent thyroid-tumor boxed warning and contraindications as semaglutide. Rare pancreatitis/gallbladder issues. Greater blood-sugar lowering if combined with other glucose-lowering medicines. Muscle loss and post-stop regain apply.
Sources
- SURMOUNT-1, NEJM 2022
- SURMOUNT-1 3-year extension, NEJM 2024
What's in the stack
- Tirzepatide + B12 injection
- Injection supplies
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Weight · Rx requiredMost popular
The Kickstart Stack
The proven first step.
- Semaglutide + B12 injection
- Insulin syringes
- Alcohol swabs
Available
$149–199/mo
Weight · Rx required
The Needle-Free Stack
All the science, none of the pokes.
- Semaglutide or tirzepatide sublingual drops
Available
$129–159/mo
Weight · Rx required
The Frontier Stack
Next-generation. Waitlist only.
- Retatrutide
Waitlist
Waitlist